ultrastructural changes of corpus luteum after ovarian stimulation at implantation period

نویسندگان

ماندانا بیگی بروجنی

mandana beigi boroujeni نسیم بیگی بروجنی

nasim beigi boroujeni مژده صالح نیا

mojdeh salehnia الهه مرندی

elahe marandi مسعود بیگی بروجنی

چکیده

background: to achieve multiple oocytes for in vitro fertilization, ovulation induction is induced by gonadotropins however, it has several effects on oocytes and embryo quality and endometrium receptivity. the aim of this study was to assess ultrastructural changes of corpus luteum after ovarian induction using human menopausal gonadotropin (hmg) and human chorionic gonadotropin (hcg) during luteal phase at implantation period. methods: female nmri mice (6-8 weeks) were divided into control and stimulated groups. in the control group, the mice were rendered pseudopregnant and in the ovarian induction group, the mice were rendered pseudopregnant after the ovarian induction. the samples were obtained from the ovary in each group at the same time during luteal phase at implantation period. ultrastructural changes were assessed using electron microscopy study. results: our results displayed some identifiable changes in ultrastructure of corpus luteum in ovarian induction group. these changes included enhancement of the apoptosis and intercellular space, whereas the angiogenesis was decreased. the findings indicated a decline in organelle density in the cytoplasm of ovarian induction, such as mitochondria, endoplasmic reticulum and polyribosome. furthermore, chromatin condensation of nuclei was observed in some cells. conclusion: the ovarian induction using hmg and hcg resulted in some ultrastructural changes on the corpus luteum at implantation period, which could affect on the pregnancy rate.

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Ultrastructural Changes of Corpus Luteum after Ovarian Stimulation at Implantation Period

Background: To achieve multiple oocytes for in vitro fertilization, ovulation induction is induced by gonadotropins however, it has several effects on oocytes and embryo quality and endometrium receptivity. The aim of this study was to assess ultrastructural changes of corpus luteum after ovarian induction using human menopausal gonadotropin (HMG) and human chorionic gonadotropin (HCG) during l...

متن کامل

Ultrastructural changes of corpus luteum after ovarian stimulation at implantation period.

BACKGROUND To achieve multiple oocytes for in vitro fertilization, ovulation induction is induced by gonadotropins; however, it has several effects on oocytes and embryo quality and endometrium receptivity. The aim of this study was to assess ultrastructural changes of corpus luteum after ovarian induction using human menopausal gonadotropin (HMG) and human chorionic gonadotropin (HCG) during l...

متن کامل

Effect of Ovarian Stimulation on the Endometrial Apoptosis at Implantation Period

Background: Apoptosis is a process that plays an important role during early stage of implantation. The aim of this study was to investigate the incidence of apoptosis in mice endometrium after ovarian stimulation at implantation period. Methods: NMRI female mice were divided into two groups: 1) control group, which were rendered pseudopregnant by vaginal stimulation and 2) experimental group, ...

متن کامل

effect of ovarian stimulation on the endometrial apoptosis at implantation period

background: apoptosis is a process that plays an important role during early stage of implantation. the aim of this study was to investigate the incidence of apoptosis in mice endometrium after ovarian stimulation at implantation period. methods: nmri female mice were divided into two groups: 1) control group, which were rendered pseudopregnant by vaginal stimulation and 2) experimental group, ...

متن کامل

Effect of ovarian stimulation on the endometrial apoptosis at implantation period.

BACKGROUND Apoptosis is a process that plays an important role during early stage of implantation. The aim of this study was to investigate the incidence of apoptosis in mice endometrium after ovarian stimulation at implantation period. METHODS NMRI female mice were divided into two groups: 1) control group, which were rendered pseudopregnant by vaginal stimulation and 2) experimental group, ...

متن کامل

Macrophages regulate corpus luteum development during embryo implantation in mice.

Macrophages are prominent in the uterus and ovary at conception. Here we utilize the Cd11b-Dtr mouse model of acute macrophage depletion to define the essential role of macrophages in early pregnancy. Macrophage depletion after conception caused embryo implantation arrest associated with diminished plasma progesterone and poor uterine receptivity. Implantation failure was alleviated by administ...

متن کامل

منابع من

با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید


عنوان ژورنال:
iranian biomedical journal

جلد ۱۶، شماره ۱، صفحات ۳۳-۳۷

میزبانی شده توسط پلتفرم ابری doprax.com

copyright © 2015-2023